Narasin (sodium salt)

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Narasin 通过神经胶质瘤细胞中的 ER 应激诱导肿瘤坏死因子相关凋亡诱导配体 (TRAIL) 介导的细胞凋亡，并通过抑制 IκBα 的磷酸化来抑制 NF-κB 信号传导。

Narasin induces tumor necrosis factor-related apoptosis-induced ligand (TRAIL)-mediated apoptosis by ER stress in glioma cells and inhibits NF-κB signaling by suppressing the phosphorylation of IκBα.(In Vitro):Narasin caused suicidal erythrocyte death or eryptosis. In human erythrocytes, Narasin increased annexin-V-binding indicating cell membrane scrambling with phosphatidylserine translocation to the erythrocyte surface and the decrease of forward scatter reflecting cell shrinkage, which indicated the death of erythrocyte. (In Vivo):Administration of 4-48 p.p.m of narasin in the pelleted feed of New Zealand White rabbits. After 4 weeks, narasin protected rabbits from severe coccidiosis induced by E. flavescens, E. perforans E. Magna, E. Intestinalis, and E. Stiedai. In addition, narasin reduced oocyst output effectively.

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HainanMycin | naransin sodium | Naracin sodium salt

Apoptosis

NF-κB

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58331-17-2

787.01

C43H71NaO11

>98% (HPLC)

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CC[C@@H](C([O-])=O)[C@H]1[C@@H](C)C[C@H](C)[C@H]([C@H]([C@H](O)[C@@H](C([C@@H]([C@@H]2[C@@H](C)C[C@@H](C)[C@@]3(C=C[C@@H](O)[C@]4(CC[C@@](C)([C@H]5CC[C@@](CC)(O)C(C)O5)O4)O3)O2)CC)=O)C)C)O1.[Na+]

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(-20℃)

With Ice Pack

≥ 2 years